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Nawigacja okruszkowa
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BIOUNCERTAINTY - ERC Starting Grant no. 805498
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10 grudnia 2020: Seminarium badawcze online - Adrian Stencel (IF UJ) ze współautorem: Drug repurposing for COVID-19: The problem of excessive hypothesis testing
Interdyscyplinarne Centrum Etyki UJ (INCET) zaprasza na seminarium badawcze w ramach projektu BIOUNCERTAINTY. Seminarium pt. “Drug repurposing for COVID-19: The problem of excessive hypothesis testing" poprowadzi Adrian Stencel (IF UJ) wraz z współautorem. Spotkanie odbędzie się w czwartek 10 grudnia o godzinie 17:30 na platformie MS Teams (link poniżej).
Abstrakt: We are concerned with the problem of excessive hypothesis testing (multiple comparisons) in the field of the search for covid-19 treatment. The problem, in our opinion, is that the current strategy of searching for the treatment is going to produce numerous false positive results. Currently, there are over 2 thousand interventional clinical trials testing the efficacy of repurposed drugs (hydroxychloroquine and remdesivir are the most widely-known examples). We argue that the prior probability of hypotheses that these drugs will be effective is very low. Considering that the number of trials is extraordinary, the repetitive sampling of the population of COVID-19 cases will lead to observing dozens of trials reporting positive results despite no effect of the treatments under test. We argue that using mechanistic evidence to assess treatments' efficacy a priori and accounting for false discovery rate could limit the amount of conflicting evidence emerging in the field and save drag approval agencies from changing their recommendations.
Adrian Stencel pracuje w Instytucie Filozofii na Uniwersytecie Jagiellońskim. Główny obszar jego zainteresowań to filozofia biologii, w szczególności teoria ewolucji, biologia populacji i mikrobiologia.
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